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A word about COVID-19 from Dr. Janette DeFelice.
It’s not about the people who get it and recover. It’s about those with compromised immune systems and the elderly. Those people will suffer and could potentially overwhelm the healthcare system so others won’t be able to get treatment for unrelated illnesses. It’s about PUBLIC health.
COVID-19 is highly transmissible. It makes you feel sick, but not too sick. So you continue to go to work and school. During that time, you are transmitting the disease to other people. Unlike a different corona virus called SARS. SARS made the victim very, very sick. Too sick to go to work. The sick person would stay home and not transmit the disease to others. Not so with COVID-19.
It’s true that a vast majority of those who come down with COVID-19 will have a mild illness and recover. But others will not recover. Because of its high transmissibility, many will get the disease (estimates range as high as 40-70% of the population). Those it hits hard (elderly, immune compromised, sometimes unpredictable) will need to be hospitalized. Hospitals can be overwhelmed with caring for these people. So much so, that if your child needs care for an unrelated illness, care or equipment may not be available.
You’ve seen the graph about flattening the curve in order to not overwhelm our healthcare system capacity. Social distancing is about flattening the curve. Again, it’s a matter of PUBLIC health.
Let me give you an analogy: Imagine COVID-19 is like one of those spiky seed pods that gets stuck on your clothing when you hike in the tall grasses. The evolutionary reason for this design is that it easily gets stuck in an animal’s fur (a deer, for example). That deer will then unwittingly transport and deposit the seed pod to another location where the seeds will grow into new plants that produce spiky seed pods that will then latch onto more deer.
Now imagine that deer has deposited that seed pod in your yard. One seed pod won’t do much harm. However, if you have multiple deer transporting those seed pods from multiple locations and depositing them in your lawn, your yard will become overwhelmed with spiky seed pod plants and you won’t be able to grow a nice garden.
In this scenario, your lawn is the hospital caring for the infirm in the midst of a COVID-19 outbreak. The garden you are trying to grow represents anyone else who may need healthcare during this time.
Two main goals at this time:
- Preventing the spread of COVID-19 to vulnerable populations.
- Preventing the healthcare system from being overwhelmed.
Social distancing is about preventing a possible public health disaster. (Labeled ‘Protective Measures’ in the graph.)
I wish you all well. Wash your hands. If you feel sick, stay home.
Janette has been endorsed by PsyPAC, “an issue-based political action committee that aims to support political candidates, legislators, and policy that promotes proactive, and evidence-based solutions. Trending epidemics are the top priority.”
Janette has also been endorsed by the United Hellenic Voters of America.
Alternatives to the Use of Ethylene Oxide as a Medical Sterilant
From: Janette DeFelice, MD, MA
Subject: Reducing the Use of Ethylene Oxide as a Medical Sterilant
Date: August 10, 2019
Hospitals are beacons of health and healing. Hospital practices should, above all, do no harm. As of the time of this writing, your hospital is participating in a practice that causes harm to workers, patients, and community members.
The use of ethylene oxide as a medical sterilant has been shown to cause pulmonary irritation and acute neurotoxic effects at best, explosions and cancer at worst. In fact, the 2014 National Air Toxics Assessment has shown that people in a community surrounding an ethylene oxide sterilization plant have a cancer risk of over 100 times the average.
Hospitals that have shifted away from the use of ethylene oxide as their method of sterilizing medical equipment have shown improvements not only in employee-, patient-, and community satisfaction, they have also seen increased efficiency and decreased cost.
Below, we recommend four options to explore:
- the Amsco®V-PRO® maX Low Temperature Sterilization System (STERIS Corporation, Mentor, OH)
- the STERRAD®100NX® Sterilizer (Advanced Sterilization Products, Irvine, CA)
- the STERIZONE®125L+ Sterilizer (TSO3, Québec, Canada)
- the Noxilizer (Baltimore, MD)
What is Ethylene Oxide?
Ethylene oxide (EtO) is an organic compound made up of two carbon atoms, 4 hydrogen atoms, and one oxygen atom. It is a highly-flammable gas at room temperature. In the past, EtO was mixed with chlorofluorocarbons (CFCs) as a diluent, but since concern over the effect of CFCs on the atmosphere, industry has shifted toward using 100% EtO for medical sterilization. This had the effect of reducing the adverse effects of the CFCs on the ozone layer, but also increased the toxic effects of the sterilant. Ethylene oxide has also been found to be carcinogenic (can be cancer-causing) , mutagenic (can cause changes in DNA of living organisms), and endocrine disrupting (can interfere with the normal activity of hormones, including sex-specific hormones) . Despite this, and despite that fact that effective alternatives exist , since the 1950s ethylene oxide has been used as a medical sterilant, specifically for heat- or moisture-sensitive medical equipment.
Disadvantages of Ethylene Oxide
- Inhalation can cause acute affects such as nausea/vomiting and neurological symptoms (lethargy, headache, dizziness, twitching)
- Highly flammable, posing explosion risk
- Mutagenic, causing changes in DNA
- Endocrine disrupting, interfering with the normal function of hormones
- Inefficient, long cycle time
Real-life Effects of Ethylene Oxide as a Medical Sterilant: Case Study
The community of Willowbrook, IL has been suffering the ill-effects of the use of EtO to sterilize medical equipment thanks to a medical sterilization plant in the area called Sterigenics. As of the mid-1980s regulators knew that those who lived near the Sterigenics plant would be exposed to more than 14 times higher than safe levels of ethylene oxide. The population exposed to this toxic chemical in Willowbrook, IL (as well as in Lake County, IL where another EtO sterilization plant exists) is estimated to be over 600,000 people. Furthermore, this map of the 2014 National Air Toxics Assessment clearly shows that people in the Willowbrook community surrounding the ethylene oxide sterilization plant have a cancer risk of over 100 times the average.
Alternatives to Using Ethylene Oxide as a Medical Sterilant
Several effective alternatives to using ethylene oxide as a medical sterilant are available. First, there is a process that uses vaporized hydrogen peroxide. It is called the Amsco® V-PRO® maX Low Temperature Sterilization System (STERIS Corporation, Mentor, OH). It uses something called a sterilization pulse, which utilizes a vacuum pulse to remove load moisture, then injects vaporized hydrogen peroxide into a chamber that is held at increased pressure, followed by air injection. The hydrogen peroxide is then converted to a harmless mixture of oxygen and water using a catalytic converter. This process does not require special venting.
The second option uses hydrogen peroxide vapor and gas plasma, called the STERRAD® 100NX® Sterilizer (Advanced Sterilization Products, Irvine, CA). Again, vaporized hydrogen peroxide is injected into a vacuum chamber. A gas plasma is then encouraged using a cycle of increased and decreased pressurization. Free radicals from the gas plasma aid in sterilization. Gases then go through a filter and are decomposed into oxygen and water vapor.
A third option, called the STERIZONE® 125L+ Sterilizer (TSO3, Québec, Canada), uses ozone and water vapor. This process also uses a vacuum chamber and hydrogen peroxide vapor. Hydroxyl radicals are then put to work to begin the sterilization process. Next, ozone is introduced for a number of cycles. Again, the exhaust is decomposed to oxygen and water. No special ventilation is needed.
Finally, the use of nitrogen dioxide is a fourth option, via the Noxilizer (Baltimore, MD). Nitrogen dioxide gas is injected into a chamber with a predetermined pressure to ensure the proper concentration of NO2gas. Then gas then enters the sterilization chamber for cycling. The nitrogen dioxide gas then goes through a neutralizing scrubber and can be vented safely.
|Ethylene Oxide||5-step process involving preconditioning and humidification, EtO gas introduction, exposure, evacuation, and air washes. Alkylating agent—disrupts DNA in microorganisms.||This process requires special venting equipment. Ethylene Oxide is released into the atmosphere.|
|Amsco® V-PRO® maX Low Temperature Sterilization System||Utilizes vaporized hydrogen peroxide (H2O2) at increased pressure.||This process does not require special venting equipment. It uses a catalytic converter to convert H2O2 to O2 and H20.|
|STERRAD® 100NX® Sterilizer||Utilizes vaporized hydrogen peroxide (H2O2) at increased pressure. Gas plasma is encouraged using cycle of increased and decreased pressurization. Free radicals aid in sterilization.||Gases go through filter and are decomposed into O2and H2O vapor.|
|STERIZONE® 125L+ Sterilizer||Utilizes ozone (O3), H2O vapor, and vaporized hydrogen peroxide (H2O2). O3 and hydroxyl radicals are used in sterilization process.||This process does not require special venting equipment. Exhaust is decomposed to O2and H2O.|
|Noxilizer||Utilizes nitrogen dioxide (NO2) gas||NO2 gas goes through a neutralizing scrubber and can be vented safely.|
Benefits of Using Non-Ethylene Oxide Methods for Medical Sterilization
Aside from the health benefits conferred onto the surrounding community and staff, using non-ethylene oxide methods for medical sterilization has other benefits—namely, cost and efficiency.
Cost:Mary Hitchcock Memorial Hospital in Lebanon, New Hampshire took on the challenges of incorporating non-ethylene oxide methods for sterilization. They found that the cost of sterilizing per square foot with the non-EtO method was significantly less than the EtO method (EtO/CO2 mix = $12.00 per square foot, EtO/HCFC mix = $11.31 per square foot, Sterrad = $8.44 per square foot). They also found that sterilization time was less and labor needed to operate the system was less leading to increase cost savings and increased efficiency .
Efficiency:When St. Joseph’s Hospital and Medical Center in Phoenix, Arizona adopted the Amsco® V-PRO® maX Low Temperature Sterilization System to replace their EtO system, they also found that sterilization time was decreased. This decrease in sterilization time increased their output load by 250%. They also found that satisfaction among physicians and staff, as well as patients, increased.
Making Changes in Your Healthcare Setting
Foster a culture of caring—Hospitals are places of respite, places of health and healing. Sterilization of medical equipment using ethylene oxide causes great harm to community members, including growing children, who are exposed to EtO emissions and to workers who are at risk of acute toxic effects, as well as being in a dangerous work environment with a flammable chemical. Look at your hospital’s mission statement and see if your hospital’s practices fit.
Open up to feedback from employees and the community—A hospital that puts the needs of the people it serves and the healthcare of its staff, workers that make hospital functioning possible, is a hospital that lives up to its purpose.
Make small changes at first—Add a non-EtO sterilization procedure to your current regime of EtO sterilizers. Measure efficiency, cost-effectiveness, employee-, patient- and community satisfaction.
Final Conclusions and Recommendations
As a healthcare setting, your hospital has an unparalleled responsibility to look toward the health of others. Whether it be employees, patients, or members of the community, your primary duty is promoting health of well-being. As every physician who walks in through your door has taken the oath ‘Primum non nocere,’ ‘First do no harm,’ your ultimate goal should be not causing harm. As shown above, using ethylene oxide to sterilize medical equipment causes harm.
Our recommendation is that you choose one of the options presented above (the Amsco® V-PRO® maX Low Temperature Sterilization System, the STERRAD® 100NX® Sterilizer, the STERIZONE® 125L+ Sterilizer, or the Noxilizer) to add to your sterilization regimen. If your hospital is not prepared to make an investment in any additional equipment at this time, another option would be to outsource sterilization of medical equipment to a company that uses one of these methods.
- Jinot, J., et al., Carcinogenicity of ethylene oxide: key findings and scientific issues.Toxicol Mech Methods, 2018. 28(5): p. 386-396.
- Norman, S., Berlin, J., Soper, K., Middendorf, B., & Stolley, P. (1995). Cancer Incidence in a Group of Workers Potentially Exposed to Ethylene Oxide. International Journal of Epidemiology, 24(2).
- Schneider, P.M., New technologies and trends in sterilization and disinfection.Am J Infect Control, 2013. 41(5 Suppl): p. S81-6.
- Hawthorne, M., Officials knew ethylene oxide was linked to cancer for decades. Here’s why it’s still being emitted in Willowbrook and Waukegan, in Chicago Tribune. 2018.
- Agency, E.P., Replacing Ethylene Oxide and Glutaraldehyde. 2002.
- Miller, R., Eliminating ETO Translates to Improved Efficiency for Phoenix Hospital, in Infection Control Today. 2014.
A short introduction to what I think is the most important campaign issue. (Spoiler: Our health!)
I gave this talk in 2017 shortly after Trump was elected.
Hi, I’m Dr. Janette DeFelice and I’m running for DuPage County Board in District 4.
I gave a talk a couple of years ago, shortly after Trump was elected about how liberals and conservatives think differently. One of the major things that stood out to me about those differences was that conservatives tend to look to the past, while liberals look to the future. I’m here because I’m looking toward our collective future. And I’m here because I have two little kids in the public school system that need to grow up healthy and know that we did everything we could to protect them.
To tell you a little about myself, I am a writer, physician, and mom. I live in Glen Ellyn with my husband, 9-year-old twins, and our cat Clara Barton. We’ve been residents of DuPage County for the last 8 years.
I’m really concerned about protecting our communities from the crippling economic and detrimental public health effects that climate change will bring to our communities.
Business as usual is not sustainable for future growth in our changing environment. I envision DuPage County embracing renewable energy and green infrastructure, supporting sustainable small businesses, and in doing so, strengthening our local economy. Our emphasis needs to be on community innovation over corporate interests.
And let me tell you something: Renewables is a $1.9 trillion industry. If we don’t get in, if we keep ourselves tethered to a past greatness that never actually was, DuPage County is going to get left behind. It’s not going to be the idyllic county with the great schools.
It’s not only about the economy. We also have to protect our health, and our children’s health. We must prepare for increased flooding brought by climate change, which brings with it disease-carrying mosquitos and ticks and has the potential to overflow our stormwater systems, by implementing green infrastructure solutions. Furthermore, we must not tolerate companies like Sterigenics that knowingly poison the air our children breathe. We must face the opioid epidemic head-on by treating it as a public health emergency.
I’d just like to talk briefly about the budget. I understand that it’s limited, and cutting staff and salaries is all the rage. But cutting funding to the DuPage Care Center (which is in the budget for 2019)? That’s just unconscionable. If we keep our money local instead of awarding contracts to big, out-of-town corporations, that money stays in circulation in our local economy. The same goes for supporting local businesses, like marijuana dispensaries. Listen, for every $100 spent in an independent local business, $48 of that stays in the community. [My time ran out before I could get to this sentence: If we spend that same $100 at an in-town chain only $14 stays in the community. And if we shop online, only $1 stays (and that’s only if the delivery driver lives locally).]
ONE SENTENCE (or two): Janette DeFelice is a forward-thinking candidate who is committed to bringing green energy and green jobs to DuPage not only to bolster a local, sustainable economy, but also to protect our health.